8:00 am Morning Coffee
8:55 am Chair’s Opening Remarks
Overcoming Quality & Scalability Hurdles to Increase Clinical Success of Circular RNAs Towards Patients in Need
9:00 am Analytical Development of Circular RNA and Novel AEX-HPLC Purity Method for Endless RNA™
Synopsis
- Exploring various methods for the analysis of circular RNAs
- Identifying the key challenges in the analytical development of high-quality eRNA™
- Discussing challenges related to purity evaluation of circular RNAs and novel analytical method
9:30 am Challenges, Solutions & Considerations in Development, Scale-up & Manufacturing of Circular RNA
Synopsis
- Discussing the specific challenges in scale-up and manufacturing circular RNA drug substance and drug product
- Exploring various technologies in process and analytics dedicated for circular RNA
10:00 am Morning Break & Networking
Successfully Develop First-in-Class Circular RNA Therapies with Groundbreaking Potentials to Treat “Incurable” Diseases
11:00 am Improving mRNA Vaccine Effectiveness & Immunogenicity for the Development of Safe Next Generation RNA Therapeutics
Synopsis
- Discussing the specific challenges related to immunogenicity in the development of RNA-based therapeutics
- Highlighting approaches to mitigate the immunogenicity of RNA molecules
- Addressing the risk of immune responses and off-target effects associated with RNA therapeutics
11:30 am Revolutionizing Therapeutics: Unveiling the CircularRNA Endogenous Biogenesis Platform
Synopsis
- Explore the groundbreaking potential of CircularRNA in revolutionizing therapeutics
- Uncover the mechanisms and applications of Circio’s CircularRNA Endogenous Biogenesis Platform
12:00 pm Lunch Break & Networking
Streamlining Clinical Success of Next Generation RNAs by Addressing Immunogenicity, Off-Target Effects & Risk Management Concerns
1:00 pm Panel Discussion: Navigating Clinical Trial Hurdles to Ensure a Streamlined Path to Clinical Adoption of RNA Therapeutics
Synopsis
- Addressing the obstacles that must be overcome to translate innovative research into real-world clinical settings
- Demonstrating how to translate different animal models
- Discussing the importance of preclinical testing, toxicity assessments, and risk management
- Evaluating to design the RNA to express in different cells
2:00 pm Afternoon Break & Networking
From COVID to Revolutionizing Cancer Treatment: Future Directions of Next Generation RNA Therapeutics Towards Regulatory Approval
3:00 pm Future Directions of Next Generation RNA Therapeutics Across a Wide Array of Diseases
Synopsis
- Highlighting the benefits and prospects of next generation RNA therapeutics compared to traditional RNA therapeutics
- Drawing cross-learnings from different systems to overcome overlapping challenges
- Learning from diverse platforms to address shared hurdles and enhance next generation RNA strategies
- Discussing how current techniques can be generated from COVID vaccines into cancer vaccines
3:30 pm Next Generation RNA-Based Therapeutics in Oncology: Current Progress & Future Prospects
Synopsis
- Emphasizing the Significance of Next Generation RNA Technologies in Revolutionizing Cancer Treatment
- Highlight specific RNA-based therapies that have shown promise in clinical trials or received regulatory approval
- Discuss the hurdles associated with delivering RNA therapeutics to tumour sites